Funding text 1: The following reagents were gifted: VCaP cells (Yong-Jie Lu, Barts Cancer Institute, UK), pcDNA3-FOXA1 (Jason Carroll, Cancer Research UK Cambridge Institute, UK), pcDNA3-myc-Flna WT (John Blenis, Beth Israel Deaconess Medical Center, USA). We thank Jernej Ule (Francis Crick Institute, UK) for providing iCounts processed data of ENCODE eCLIP experiments. This research has received funding from AIRC under MFAG 2017 ID 20566 (to M.C.) and IG 2017 ID 20240 (to S.O.), FPRC 5xmille 2018 Ministero Salute, project "ADVANCE/A-Bi-C": Italian Ministry of Health, Ricerca Corrente 2021 (to M.C.), the Compagnia di San Paolo (to M.C.), joint Royal College of Surgeons of England/Cancer Research UK Clinician Scientist Fellowship in Surgery (C19198/A15339 to P.R.), The Urology Foundation and John Black Charitable Foundation (to P.R.), The Royal College of Surgeons of England (PO117626 to P.R.) Barts Charity (MGU0533 to P.R.), and Orchid Charity (to P.R.). We sincerely thank Giuseppe Basso (1948–2021) for his guidance, teaching, and dedication to foster research programs aimed at the needs of patients. Conceptualization, M.D.G. J.G.F. S.P. P.R. and M.C.; methodology, M.D.G. J.G.F. S.P. A.R. and M.C.; software, M.D.G. S.P. A.R. and M.C.; validation, M.D.G. J.G.F. and S.P.; formal analysis, M.D.G. S.P. and A.R.; investigation, M.D.G. J.G.F. S.P. A.R. L.C. F.G. C.P. F.A. R.A. and S.G.; resources, S.O. G.B. P.R. and M.C.; data curation, M.D.G. J.G.F. and S.P.; writing – original draft, M.D.G. J.G.F. S.P. A.R. P.R. and M.C.; writing – review & editing, M.D.G. J.G.F. P.R. and M.C.; visualization, M.D.G. J.G.F. P.R. and M.C.; supervision, P.R. and M.C.; project administration, P.R. and M.C.; funding acquisition, P.R. and M.C. The authors declare no competing interests.; Funding text 2: The following reagents were gifted: VCaP cells (Yong-Jie Lu, Barts Cancer Institute, UK), pcDNA3-FOXA1 (Jason Carroll, Cancer Research UK Cambridge Institute, UK), pcDNA3-myc-Flna WT (John Blenis, Beth Israel Deaconess Medical Center, USA). We thank Jernej Ule (Francis Crick Institute, UK) for providing iCounts processed data of ENCODE eCLIP experiments. This research has received funding from AIRC under MFAG 2017 ID 20566 (to M.C.) and IG 2017 ID 20240 (to S.O.), FPRC 5xmille 2018 Ministero Salute, project "ADVANCE/A-Bi-C": Italian Ministry of Health, Ricerca Corrente 2021 (to M.C.), the Compagnia di San Paolo (to M.C.), joint Royal College of Surgeons of England /Cancer Research UK Clinician Scientist Fellowship in Surgery ( C19198/A15339 to P.R.), The Urology Foundation and John Black Charitable Foundation (to P.R.), The Royal College of Surgeons of England ( PO117626 to P.R.) Barts Charity ( MGU0533 to P.R.), and Orchid Charity (to P.R.). We sincerely thank Giuseppe Basso (1948–2021) for his guidance, teaching, and dedication to foster research programs aimed at the needs of patients.